Solubility: easily soluble in ethanol, insoluble in chloroform; Soluble in glacial acetic acid, dissolved in sodium hydroxide test solution.

 

Specific rotation: 60°( c=2, EtOH )

 

Boiling point: 437.26°C ( rough estimate )

 

Flashing point: 9°C

 

Water solubility: pratically insoluble

 

Merck: 14,9889

 

Pharmacologic action:  Ursodeoxycholic acid (3α, 7β-dihydroxy cholic acid) is the 7β-hydroxy differential isomer of goanodeoxycholic acid. It is this slight difference in structure that makes this product hydrophilic. This product can reduce the activity of β-hydroxy-β-methylglutaryl Coenzyme A(HMG-CoA) reductase, which is the rate-limiting enzyme of cholesterol synthesis in liver, and inhibit cholesterol synthesis. And form stable liquid crystalline suspensions with cholesterol, so that the cholesterol in the bile unsaturated, and then promote the cholesterol in the stone precipitation and dissolution. This product can also inhibit intestinal absorption of cholesterol. Ursodeoxycholic acid can also antagonize the cytotoxicity of endogenous hydrophobic bile acids and protect liver cell membrane. This product reduces the overexpression of the major histocompatibility antigen MHC-1 in liver cell membrane; Inhibition of interleukin-2, 4, tumor necrosis factor and interferon alpha production; Increase the level of interleukin-10chemicalbook and 12 in the body; And directly bind to glucocorticoid receptors to play an immunomodulatory role. In addition, ursodeoxycholic acid can inhibit cell apoptosis, inhibit inflammation, clear free radicals and antioxidant activities. After oral administration, the absorption was mainly in the upper jejunum by non-ionic passive diffusion mode and in the ileum by active transport mode. The first pass effect was large, and 50% ~ 75% of the oral dose was absorbed by the liver. It is mainly distributed in liver, intestine and plasma, and the binding rate of plasma protein is 96% ~ 99%. Ursodeoxycholic acid concentration in bile increased in a dose-dependent manner. When the dose is 20-30 mg/(kg·d), the concentration in bile is more than 60%, which can achieve the best therapeutic effect. Combined with glycine and taurine in the liver, it is metabolized by intestinal bacteria in the colon. A small part of the metabolites are excreted in the urine, and most of them are excreted in the stool. The biological half-life is 3.5 to 5.8 days when taken orally.

 

Attribute
[Chem Name]	Ursodeoxycholic acid
[CAS No.]	128-13-2
[EINECS]	204-879-3
[MDL No.]	MFCD00003680
[Formula]	C24H40O4
[Molecular]	392.57
[Form]	White to Almost white powder to crystaline
[Risk Codes]	GHS07
[Storage]	2-8 °C
[Synonym]	Tauroursodiol;Urosodeoxycholic Acid;Ursodeoxycholic acid(micronized);URSODEOXYCHOLIC ACID;URSODESOXYCHOLIC ACID;URSODIOL;URSODEOXYCHOLOC ACID;UDCA

Goods Tag