GSK778 (iBET-BD1) is a BD1 bromine domain inhibitor of BET protein with IC50 value of 75 nM for BRD2 BD1, 41 nM for BRD3 BD1, 41 nM for BRD4 BD1 and 143 nM for BRDT BD1.

 

Brand: BCM

 

Boiling Point: 679.6±55.0 °C(Predicted)

 

pKa: 9.90±0.10(Predicted)

 

Solubility: Soluble in DMSO : 41.67 mg/mL (81.45 mM; Need ultrasonic). Insoluble in Water.

 

InChi Key: ZORLJXWXFABTPZ-CTNGQTDRSA-N

 

Attribute
[Chem Name]	4-(2-(methoxymethyl)-1-((R)-1-phenylethyl)-8-(((S)-pyrrolidin-3-yl)methoxy)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole
[Synonym]	GSK778; GSK-778; GSK 778; iBET-BD1
[CAS No.]	2451862-42-1
[MDL No.]	MFCD33402173
[Formula]	C30H33N5O3
[Molecular]	511.61
[Form]	Solid powder

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