NSC321039, also known as hMAO-B-IN-4, is a selective, reversible and blood–brain barrier (BBB) penetrable human monoamine oxidase-B (hMAO-B) inhibitor with an IC50 value of 0.067 μM. This compound was reported in Scientific Reports (2022), 12(1), 22404 NSC321039 was reversible inhibitor of hMAO-B. PAMPA assay manifested that NSC321039 had a significant permeability and CNS bioavailability with Pe value higher than 4.0 x 10-6 cm/s. NSC321039 was stabilized in protein-ligand complexes by the π-π stacking, which enabled them to bind to the hMAO-B enzyme′s active site incredibly effectively.

 

Brand: BCM

 

InChi Key: MKSMRBDQELHEBO-JLHYYAGUSA-N

 

Attribute
[Chem Name]	(2E)-3-[4-(benzyloxy)phenyl]-1-(thiophen-2-yl)prop-2-en-1-one
[Synonym]	NSC321039; NSC-321039; NSC 321039
[CAS No.]	1666119-75-0
[MDL No.]	MFCD01893914
[Formula]	C20H16O2S
[Molecular]	320.4
[Storage]	Refrigerator

Goods Tag