Nf-κb-in-1 is an effective inhibitor of NF-κB signaling pathway, acting its role over inhibitory inhibitory inhibitory factor (IKK).

 

Brand: BCM

 

Boiling Point: 732.0±60.0°C at 760 mmHg

 

Solubility: Soluble in DMSO. Insoluble in Water.

 

InChIKey: AYIYVEPNEPUJCF-GNXRPPCSSA-N

 

Targets: IKK [1]

 

In Vitro:  Nafa-κb-in-1 (Compound 17) (0.001-100 μm); 72h) inhibited the growth of A549, H1944, H460 and H157 cells, and the GI50s were 0.72, 0.07, 0.13 and 0.16μM, respectively [1]. Nafa-κb-in-1 (0.5-25 IN) μm; Pretreatment for 30 min or 4 h) can effectively block the phosphorylation and degradation of IκB A549 cells [1]. Nafa-κb-in-1 (0.1-100) μm; Pretreatment for 30 min) inhibited TNF-α-induced nuclear factor shift-κB in a dose-dependent way in A549 cells, with IC50s of 1.0μM[1]. Nafa-κb-in-1 (0.1-0.4 μm; 9 d) inhibit lung cancer clonogenesis activity [1]. Cell viability determination [1] Cell line: A549, H1944, H460, H157 Cell concentration: 0.001, 0.01, 0.1, 1, 10, 100μM Incubation time: 72h Results: The activity of lung adenocarcinoma cell A549, H1944, squamous cell carcinoma cell H157 and large cell carcinoma cell H460 decreased in a dose-dependent manner. westernblot analysis [1] Cell line: A549 cell concentration: 0.5, 1.0, 2.5, 5.0, 10.0, 25.0μM Incubation time: pretreatment for 30 min or 4 h Results: blocking phosphorylation of IκB, IC50 was 2.8μM. Prevent dose-dependent degradation of IκB.

 

Reference:

 

[1]. Qiu X, et, al. Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-κB signaling pathway. J Med Chem. 2010 Dec 9;53(23):8260-73. 

 

Attribute
[Chem Name]	(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4-(4-hydroxy-3-methoxybenzylidene)hepta-1,6-diene-3,5-dione
[CAS No.]	1227098-15-8
[Formula]	C31H30O8
[Molecular]	530.57
[Storage]	-20°C
[Synonym]	NF-κB-IN-1

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