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UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 binds TNF with Kd of 13 nM. UCB-9260 also inhibits NF-κB with IC50 of 202 nM after TNF stimulation.
Brand: BCM
Solubility: Soluble in DMSO.
InChi Key: RZGFWGNCSYUEPR-UHFFFAOYSA-N
Attribute [Chem Name] (1-(2,5-dimethylbenzyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-2-yl)(pyridin-4-yl)methanol [Synonym] UCB-9260; UCB 9260; UCB9260 [CAS No.] 1515888-53-5 [Formula] C26H25N5O [Molecular] 423.52 [Storage] 2-8 °C
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