Dabrafenib (GSK2118436, GSK2118436A) is a BRAFV600E mutant specific inhibitor with an IC50 of 0.7 nM in a cell free assay, which is 7 and 9 times less effective against B-Raf(wt) and c-Raf, respectively.

 

Brand: BCM

 

Melting Point: 204 ~ 216 °C

 

Boiling Point: 653.7±65.0 °C(Predicted)

 

Solubility: Soluble in DMSO (up to 30 mg/ml with warming), or in Ethanol (up to 1 mg/ml with warming).

 

pKa: 6.62±0.10(Predicted)

 

Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

 

GHS: GHS08, GHS09

 

Isomeric SMILES: CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F  

 

InChIKey: BFSMGDJOXZAERB-UHFFFAOYSA-N  

 

InChI: InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)  

 

Attribute
[Chem Name]	N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
[Synonym]	Dabrafenib, GSK2118436, GSK-2118436
[CAS No.]	1195765-45-7
[EINECS]	689-166-9
[MDL No.]	MFCD17215684
[Formula]	C23H20F3N5O2S2
[Molecular]	519.56
[Form]	White solid
[Storage]	-20°C

Goods Tag