WYE-125132 (WYE-132) is a highly effective, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; Action on mTOR is more selective than action on PI3Ks or PI3K-related kinases hSMG1 and ATR.

 

Brand: BCM

 

Signaling Pathways: Apoptosis; PI3K/Akt/mTOR signaling

 

Melting Point: 162-184°C (dec.)

 

pKa: 13.82±0.46(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7  

 

InChIKey: QLHHRYZMBGPBJG-UHFFFAOYSA-N  

 

InChI: InChI=1S/C27H33N7O4/c1-28-26(35)30-18-4-2-17(3-5-18)23-31-24(33-15-20-6-7-21(16-33)38-20)22-14-29-34(25(22)32-23)19-8-10-27(11-9-19)36-12-13-37-27/h2-5,14,19-21H,6-13,15-16H2,1H3,(H2,28,30,35)  

 

Attribute
[Chem Name]	1-[4-[1-(1,4-dioxaspiro[4.5]decan-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-3-methylurea
[Synonym]	WYE-132; WYE132; WYE 132; WYE-125132
[CAS No.]	1144068-46-1
[MDL No.]	MFCD22420813
[Formula]	C27H33N7O4
[Molecular]	519.6
[Form]	White powder solid
[Storage]	Sealed in dry. -20°C

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