RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.

 

Brand: BCM

 

pKa: 9.19±0.20(Predicted)

 

Signaling Pathways: Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells

 

Target Acitvity: cyclin T1-CDK9:1 nM, cyclin E-CDK3:5 nM, cyclin D1-CDK4:4 nM, cyclin E-CDK2:3 nM, cyclin B1-CDK1:2 nM

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: COCCN1CCN(CC1)CC2=CC=C(C=C2)C3=NNC4=C3C(=O)C5=C4C=CC=C5NC(=O)NN6CCOCC6  

 

InChIKey: XLSYZSRXVVCHLS-UHFFFAOYSA-N  

 

InChI: InChI=1S/C29H35N7O4/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36/h2-8H,9-19H2,1H3,(H,31,32)(H2,30,33,38) 

 

Attribute
[Chem Name]	1-[3-[4-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]phenyl]-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-ylurea
[Synonym]	RGB-286638 free base; RGB286638
[CAS No.]	784210-88-4
[Formula]	C29H35N7O4
[Molecular]	545.63
[Form]	Light yellow to green yellow powder
[Storage]	Powder: -20°C for 3 years In solvent: -80°C for 2 years

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