ErbB-2 Inhibitor is an EGFR, ErbB2 and ErbB4 inhibitor with IC50 of 0.017 μM, 0.08 μM and 1.91 μM, respectively.

 

Brand: BCM

 

Signaling Pathways: Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors

 

Target Activity: EGFR:20 nM , c-ErbB2:79 nM

 

Solubility: Soluble in DMSO; Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)OCC4=CC=CC=C4)OC  

 

InChIKey: DNOKYISWMVFYFA-UHFFFAOYSA-N  

 

InChI: InChI=1S/C23H21N3O3/c1-27-21-12-19-20(13-22(21)28-2)24-15-25-23(19)26-17-8-10-18(11-9-17)29-14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,24,25,26)

 

Attribute
[Chem Name]	6,7-dimethoxy-N-(4-phenylmethoxyphenyl)quinazolin-4-amine
[Synonym]	EGFR/ErbB-2 Inhibitor;
[CAS No.]	179248-61-4
[MDL No.]	MFCD08758375
[Formula]	C23H21N3O3
[Molecular]	387.43
[Form]	Crystalline solid
[Storage]	Sealed in dry. Stored at 4°C, protect from light.

Goods Tag