Hispidulin (Dinatin), a naturally active ingredient found in many traditional Chinese herbs, has inhibitory activity against oncoprotein kinase Pim-1 with an IC50 value of 2.71 μM. Hispidulin induces apoptosis through mitochondrial dysfunction and inhibits the P13k/Akt signaling pathway in HepG2 cancer cells. Hispidulin plays an anti-osteoporosis and reduced bone resorption role by activating AMPK signaling pathway.

 

Brand: BCM

 

Melting Point: 291-292 °C

 

Boiling Point: 601.5±55.0 °C(Predicted)

 

pKa: 6.51±0.40(Predicted)

 

Solubility: Soluble in DMSO.

 

Isomeric SMILES: COC1=C(C2=C(C=C1O)OC(=CC2=O)C3=CC=C(C=C3)O)O  

 

InChIKey: IHFBPDAQLQOCBX-UHFFFAOYSA-N  

 

InChI: InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3

 

Attribute
[Chem Name]	5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one
[Synonym]	Hispidulin; Dinatin
[CAS No.]	1447-88-7
[MDL No.]	MFCD00143504
[Formula]	C16H12O6
[Molecular]	300.26
[Form]	White to beige powder
[Storage]	Sealed in dry. Store in freezer, under -20°C

Goods Tag