MGH-CP1 is an autopalmitylation inhibitor of TEAD2 (IC50:710 nM) and TEAD4 (IC50:672 nM). Mgh-cp1 is orally active and can reduce the palmitylation levels of TEAD protein expressed in cells endogenous or ectopically. MGH-CP1 and Lats1/2 were absent, which inhibited the expression of Myc, hindered the excessive proliferation of epithelial cells, and induced cell apoptosis.

 

Brand: BCM

 

Target Activity: TEAD2:672 nM, TEAD4:710 nM

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: C1C2CC3CC1CC(C2)(C3)C4=CC=C(C=C4)NC(=O)CSC5=NC=NN5  

 

InChIKey: UUKXOVBCMOZQNC-UHFFFAOYSA-N  

 

InChI: InChI=1S/C20H24N4OS/c25-18(11-26-19-21-12-22-24-19)23-17-3-1-16(2-4-17)20-8-13-5-14(9-20)7-15(6-13)10-20/h1-4,12-15H,5-11H2,(H,23,25)(H,21,22,24) 

 

Attribute
[Chem Name]	N-[4-(1-adamantyl)phenyl]-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide
[Synonym]	MGH-CP1
[CAS No.]	896657-58-2
[EINECS]	816-922-9
[MDL No.]	MFCD07361635
[Formula]	C20H24N4OS
[Molecular]	368.5
[Form]	Solid
[Storage]	4°C, sealed storage, away from moisture and light

Goods Tag