A-674563 is a potent and selective Akt1 inhibitor with Ki of 11 nM. A-674563 suppressed the activation of the NLRP3 inflammasome in cardiomyocytes following β-adrenoceptor activation, suggesting that AKT1 is a critical regulator molecule upstream of the NLRP3 inflammasome. A-674563 suppresses CDK2 activity, inhibits human NSCLC cell growth more effectively than the pan-AKT inhibitor, MK-2206

 

Brand: BCM

 

Solubility: Soluble in DMSO; soluble in Water.

 

Isomeric SMILES: CC1=C2C=C(C=CC2=NN1)C3=CC(=CN=C3)OC[C@H](CC4=CC=CC=C4)N.Cl  

 

InChIKey: HLNHYVLLEFHBJD-FYZYNONXSA-N  

 

InChI: InChI=1S/C22H22N4O.ClH/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16;/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26);1H/t19-;/m0./s1

 

Attribute
[Chem Name]	(2S)-1-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxy-3-phenylpropan-2-amine;hydrochloride
[Synonym]	A-674563 HCl; A-674563 hydrochloride; A-674563; A674563; A 674563;
[CAS No.]	2070009-66-2
[MDL No.]	MFCD18711680
[Formula]	C22H23ClN4O
[Molecular]	394.9
[Form]	Solid
[Storage]	4°C, stored under nitrogen

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