RR-11a analog is a potent and irreversible inhibitor of Schistosoma mansoni legumain. Its IC50 is 31 nM. RR-11a analog is a derivative of aza-Asn and a receptor for aza-peptide Michael.

 

Brand: BCM

 

Signaling Pathways: Microbiology/Virology

 

Target Activity: AE1 in Trichomonas Vaginalis:4.5 nM , AE in Ixodes ricinus:4.5 nM , AE in Schistosoma mansoni:31 nM

 

Solubility: Soluble in DMSO.

 

Isomeric SMILES: CCOC(=O)/C=C/C(=O)N(CC(=O)N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OCC1=CC=CC=C1  

 

InChIKey: YGVKPQSVBJEMMQ-BWLFODOESA-N  

 

InChI: InChI=1S/C22H29N5O8/c1-4-34-19(30)11-10-18(29)27(12-17(23)28)26-21(32)15(3)24-20(31)14(2)25-22(33)35-13-16-8-6-5-7-9-16/h5-11,14-15H,4,12-13H2,1-3H3,(H2,23,28)(H,24,31)(H,25,33)(H,26,32)/b11-10+/t14-,15-/m0/s1 

 

Attribute
[Chem Name]	ethyl (E)-4-[(2-amino-2-oxoethyl)-[[(2S)-2-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]propanoyl]amino]amino]-4-oxobut-2-enoate
[Synonym]	RR-11a analog; aza-peptide Michael acceptor, 7a
[CAS No.]	685543-66-2
[MDL No.]	MFCD31813786
[Formula]	C22H29N5O8
[Molecular]	491.49
[Form]	White to off-white solid
[Storage]	Powder: -20°C for 3 years. In solvent: -80°C for 2 years

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