TH5487 is a selective active site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with an IC50 of 342 nM.

 

Brand: BCM

 

In Vitro: TH5487 Inhibited proinflammatory gene expression dose-dependently.

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: C1CN(CCC1N2C3=C(C(=CC=C3)Br)NC2=O)C(=O)NC4=CC=C(C=C4)I  

 

InChIKey: FZLKVWWPFOLPKF-UHFFFAOYSA-N  

 

InChI: InChI=1S/C19H18BrIN4O2/c20-15-2-1-3-16-17(15)23-19(27)25(16)14-8-10-24(11-9-14)18(26)22-13-6-4-12(21)5-7-13/h1-7,14H,8-11H2,(H,22,26)(H,23,27) 

 

Attribute
[Chem Name]	4-(4-bromo-2-oxo-3H-benzimidazol-1-yl)-N-(4-iodophenyl)piperidine-1-carboxamide
[Synonym]	TH5487; TH-5487; TH 5487
[CAS No.]	2304947-71-3
[MDL No.]	MFCD31811638
[Formula]	C19H18BrIN4O2
[Molecular]	541.18
[Form]	Solid
[Storage]	Sealed in dry, 2-8°C

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