KGA-2727 is a potent, selective and high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki values of 97.4 nM for human SGLT1 and 43.5 nM for rat SGLT1. The selectivity ratio of KGA-2727 (Ki for SGLT2/Ki for SGLT1) is 140 (human) and 390 (rat). KGA-2727 has shown antidiabetic efficacy in rodent models.

 

Brand: BCM

 

Boiling Point: 839.6±65.0 °C(Predicted)

 

pKa: 12.65±0.70(Predicted)

 

Signaling Pathways: GPCR/G Protein

 

Solubility: Soluble in DMSO; soluble in Water; soluble in Ethanol.

 

Isomeric SMILES: CC1=C(C=CC(=C1)OCCCNCCC(=O)N)CC2=C(NN=C2O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)C(C)C  

 

InChIKey: MDBARDSTXONTFS-MNDUUMEHSA-N  

 

InChI: InChI=1S/C26H40N4O8/c1-14(2)21-18(25(30-29-21)38-26-24(35)23(34)22(33)19(13-31)37-26)12-16-5-6-17(11-15(16)3)36-10-4-8-28-9-7-20(27)32/h5-6,11,14,19,22-24,26,28,31,33-35H,4,7-10,12-13H2,1-3H3,(H2,27,32)(H,29,30)/t19-,22-,23+,24-,26+/m1/s1

 

Attribute
[Chem Name]	3-[3-[3-methyl-4-[[5-propan-2-yl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1H-pyrazol-4-yl]methyl]phenoxy]propylamino]propanamide
[Synonym]	KGA-2727
[CAS No.]	666842-36-0
[Formula]	C26H40N4O8
[Molecular]	536.63
[Form]	Solid
[Storage]	4°C, protect from light

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