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Z-JIB-04 (NSC 693627, JIB-04 Z-isomer) is an isomer of JIB-04. JIB-04 is a pan-selective inhibitor of Jumonji histone demethylase, The IC50 values for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C and JMJD2D are 230 nM, 340 nM, 855 nM, 445 nM, 435 nM, 1100 nM and 290 nM, respectively. (Z)-JIB-04 was inactive in epigenetic analysis.
Brand: BCM
Boiling Point: 472.9±55.0 °C(Predicted)
pKa: 11.00±0.10(Predicted)
Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.
Isomeric SMILES: C1=CC=C(C=C1)/C(=N/NC2=NC=C(C=C2)Cl)/C3=CC=CC=N3
InChIKey: YHHFKWKMXWRVTJ-XLNRJJMWSA-N
InChI: InChI=1S/C17H13ClN4/c18-14-9-10-16(20-12-14)21-22-17(13-6-2-1-3-7-13)15-8-4-5-11-19-15/h1-12H,(H,20,21)/b22-17-
Attribute [Chem Name] 5-chloro-N-[(Z)-[phenyl(pyridin-2-yl)methylidene]amino]pyridin-2-amine [Synonym] Z-JIB-04; NSC 693627; JIB-04 Z-isomer [CAS No.] 199596-24-2 [MDL No.] MFCD28347704 [Formula] C17H13ClN4 [Molecular] 308.76 [Form] Solid [Storage] Keep in dark place. Inert atmosphere. Store in freezer, under -20°C
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