EZM0414 is a potent, selective, and orally available inhibitor of Histone-lysine N-methyltransferase SETD2 (SETD2).

 

Brand: BCM

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC1=C2C(=C(C=C1)F)C=C(N2)C(=O)N[C@@H]3CCC[C@@H](C3)N4CCN(CC4)C(=O)C  

 

InChIKey: PGNLXEBQMQHFNK-SJORKVTESA-N  

 

InChI: InChI=1S/C22H29FN4O2/c1-14-6-7-19(23)18-13-20(25-21(14)18)22(29)24-16-4-3-5-17(12-16)27-10-8-26(9-11-27)15(2)28/h6-7,13,16-17,25H,3-5,8-12H2,1-2H3,(H,24,29)/t16-,17+/m1/s1 

 

Attribute
[Chem Name]	N-[(1R,3S)-3-(4-acetylpiperazin-1-yl)cyclohexyl]-4-fluoro-7-methyl-1H-indole-2-carboxamide
[Synonym]	EZM0414; EZM 0414; EZM-0414
[CAS No.]	2411748-50-8
[Formula]	C22H29FN4O2
[Molecular]	400.5
[Storage]	Powder: -20°C for 3 years. In solvent: -80°C for 2 years

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