FB23 directly binds to FTO and selectively inhibits FTO's m6A demethylase activity. (FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis.)

 

Brand: BCM

 

Target: FTO:60 nM (IC50)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: CC1=C(C(=NO1)C)C2=CC(=C(C(=C2)Cl)NC3=CC=CC=C3C(=O)O)Cl  

 

InChIKey: VUXZATVQMFSUCM-UHFFFAOYSA-N  

 

InChI: InChI=1S/C18H14Cl2N2O3/c1-9-16(10(2)25-22-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(23)24/h3-8,21H,1-2H3,(H,23,24)

 

Attribute
[Chem Name]	2-[2,6-dichloro-4-(3,5-dimethyl-1,2-oxazol-4-yl)anilino]benzoic acid
[Synonym]	FB23
[CAS No.]	2243736-35-6
[MDL No.]	MFCD32669807
[Formula]	C18H14Cl2N2O3
[Molecular]	377.22
[Storage]	Stored at -20°C

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