Laduviglusib (SIRI-99021, CT99021) is an inhibitor of GSK-3α and GSK-3β with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 has no cross-reactivity to CDKs and is 350 times more selective to GSK-3β than to CDKs. Cher-99021 acts as an activator of Wnt/β-catenin and induces autophagy.

Brand: BCM

 

Target: Autophagy; Wnt/beta-catenin; GSK-3

 

Signaling Pathways: PI3K/Akt/mTOR signaling; Autophagy; Cytoskeletal Signaling; Stem Cells

 

Boiling Point: 784.1±70.0 °C at 760 mmHg

 

Flashing Point: 428.0±35.7 °C

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS06

 

Isomeric SMILES: CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N  

 

InChIKey: AQGNHMOJWBZFQQ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)

 

Attribute
[Chem Name]	6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile
[Synonym]	Laduviglusib; CHIR-99021; CT99021
[CAS No.]	252917-06-9
[EINECS]	809-015-4
[MDL No.]	MFCD11846251
[Formula]	C22H18Cl2N8
[Molecular]	465.34
[Form]	White to light brown powder
[Storage]	Keep in dark place. Inert atmosphere. Store in freezer, under -20°C

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