TWS119 is a GSK-3β inhibitor with an IC50 of 30 nM in cell-free trials. It can induce the differentiation of nerve cells and contribute to the study of stem cell biology. Inhibition of GSK-3β triggers autophagy.

 

Brand: BCM

 

Target: Autophagy; GSK-3

 

Signaling Pathways: Autophagy; Stem Cells; PI3K/Akt/mTOR signaling

 

Boiling Point: 646.0±55.0 °C at 760 mmHg

 

Melting Point: 249 °C

 

Flashing Point: 344.5±31.5 °C

 

Solubility: Soluble in DMSO. Insoluble in Ethanol; insoluble in Water.

GHS: GHS07

 

Isomeric SMILES: C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O  

 

InChIKey: VPVLEBIVXZSOMQ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)

 

Attribute
[Chem Name]	3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
[Synonym]	TWS119; TWS-119; GSK inhibitor XII
[CAS No.]	601514-19-6
[EINECS]	637-358-8
[MDL No.]	MFCD09037535
[Formula]	C18H14N4O2
[Molecular]	318.33
[Form]	White to beige powder
[Storage]	Keep in dark place. Sealed in dry, 2-8°C

Goods Tag