IU1 is a cytoosmotic, reversible selective inhibitor of proteasome (proteasome) with IC50 of 4.7 μM for USP14 and 25 times higher selectivity for IsoT. IU1 can induce autophagy.

 

Brand: BCM

 

Target: DUB; Autophagy

 

Signaling Pathways: Autophagy; Ubiquitination; Cell Cycle/Checkpoint; DNA Damage/DNA Repair

 

Boiling Point: 437.0±45.0 °C at 760 mmHg

 

Flashing Point: 218.1±28.7 °C

 

Vapour Pressure: 0.0±1.0 mmHg at 25°C

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

pKa: 8.20±0.20(Predicted)

 

GHS: GHS05

 

Isomeric SMILES: CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3  

 

InChIKey: JUWDSDKJBMFLHE-UHFFFAOYSA-N  

 

InChI: InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3

 

Attribute
[Chem Name]	1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone
[Synonym]	IU1
[CAS No.]	314245-33-5
[MDL No.]	MFCD01917473
[Formula]	C18H21FN2O
[Molecular]	300.37
[Form]	Off-white to light brown powder
[Storage]	2-8°C
[EINECS]	686-043-1

Goods Tag