Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with an IC50 of 2 nM/3 nM/6 nM. It has similar inhibitory activity against Kit (c-Kit) and is 10 times more selective to VEGFR than PDGFR and Ret. Phase 3.

 

Brand: BCM

 

Target: Kit:8 nM, VEGFR2/Flk1:6 nM, VEGFR1:2 nM, VEGFR3:6 nM, VEGFR2:3 nM

 

Signaling Pathways: Angiogenesis; Tyrosine Kinase/Adaptors

 

Solubility: Soluble in DMSO (warmed with 50ºC water bath); soluble in Water (warmed with 50ºC water bath). Insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C.OP(=O)(O)O.OP(=O)(O)O  

 

InChIKey: ONDPWWDPQDCQNJ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C22H23N5O.2H3O4P/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15;2*1-5(2,3)4/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28);2*(H3,1,2,3,4)

 

Attribute
[Chem Name]	N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide;phosphoric acid
[Synonym]	AMG-706; Motesanib Diphosphate
[CAS No.]	857876-30-3
[MDL No.]	MFCD12407403
[Formula]	C22H29N5O9P2
[Molecular]	569.441282
[Form]	Powder
[Storage]	Inert atmosphere. Store in freezer, under -20°C

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