Naloxegol oxalate (NKTR-118 oxalate) is a μ-opioid receptor antagonist with a Ki value of 33.8nM. Naloxegol oxalate inhibits the binding of opioids to μ-opioid receptors in the gastrointestinal tract and is effective in relieving opioid-induced constipation.

 

Brand: BCM

 

Melting Point: 92-95°C

 

Target: P450

 

Signaling Pathways: Metabolism

 

Solubility: Soluble in DMSO; soluble in Ethanol; soluble in Water. 

 

GHS: GHS05, GHS08, GHS07

 

Isomeric SMILES: COCCOCCOCCOCCOCCOCCOCCO[C@H]1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC=C)O.C(=O)(C(=O)O)O  

 

InChIKey: MNYIRXLCPODKLG-VUTNLTPYSA-N  

 

InChI: InChI=1S/C34H53NO11.C2H2O4/c1-3-9-35-10-8-33-30-26-4-5-27(36)31(30)46-32(33)28(6-7-34(33,37)29(35)25-26)45-24-23-44-22-21-43-20-19-42-18-17-41-16-15-40-14-13-39-12-11-38-2;3-1(4)2(5)6/h3-5,28-29,32,36-37H,1,6-25H2,2H3;(H,3,4)(H,5,6)/t28-,29+,32-,33-,34+;/m0./s1 

 

Attribute
[Chem Name]	(4R,4aS,7S,7aR,12bS)-7-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol;oxalic acid
[Synonym]	Naloxegol oxalate; NKTR-118 oxalate
[CAS No.]	1354744-91-4
[EINECS]	1592732-453-0
[MDL No.]	MFCD29472292
[Formula]	C36H55NO15
[Molecular]	741.83
[Form]	White to Off-White Solid
[Storage]	-20°C Freezer. Under inert atmosphere

Goods Tag