SB225002 is a potent selective CXCR2 antagonist that inhibits the binding of interleukin IL-8 to CXCR2 with an IC50 of 22 nM, which is more than 150 times more selective than other 7-TMRs tested.

 

Brand: BCM

 

Target: CXCR

 

Signaling Pathways: GPCR/G Protein; Immunology/Inflammation; Autophagy

 

Boiling Point: 401.6±45.0 °C(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol (warmed with 50ºC water bath). Insoluble in Water.

 

pKa: 5.29±0.10(Predicted)

 

GHS: GHS07

 

Isomeric SMILES: C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br  

 

InChIKey: MQBZVUNNWUIPMK-UHFFFAOYSA-N  

 

InChI: InChI=1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)

 

Attribute
[Chem Name]	1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
[Synonym]	SB225002; SB 225002
[CAS No.]	182498-32-4
[MDL No.]	MFCD00954637
[Formula]	C13H10BrN3O4
[Molecular]	352.14
[Form]	White to yellow solid
[Storage]	Inert atmosphere. Store in freezer, under -20°C

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