GLPG0974 is an antagonist of FFA2/GPR43 with an IC50 of 9 nM.

 

Brand: BCM

 

Target: GPR 43:9 nM

 

Signaling Pathways: GPCR/G Protein; Endocrinology/Hormones

 

Boiling Point: 726.3±60.0 °C(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol.

 

pKa: 4.63±0.10(Predicted)

 

Isomeric SMILES: C[C@@]1(CCN1C(=O)C2=CSC3=CC=CC=C32)C(=O)N(CCCC(=O)O)CC4=CC(=CC=C4)Cl  

 

InChIKey: MPMKMQHJHDHPBE-RUZDIDTESA-N  

 

InChI: InChI=1S/C25H25ClN2O4S/c1-25(11-13-28(25)23(31)20-16-33-21-9-3-2-8-19(20)21)24(32)27(12-5-10-22(29)30)15-17-6-4-7-18(26)14-17/h2-4,6-9,14,16H,5,10-13,15H2,1H3,(H,29,30)/t25-/m1/s1 

 

Attribute
[Chem Name]	4-[[(2R)-1-(1-benzothiophene-3-carbonyl)-2-methylazetidine-2-carbonyl]-[(3-chlorophenyl)methyl]amino]butanoic acid
[Synonym]	GLPG0974; GLPG 0974; GLPG-0974; MPMKMQHJHDHPBE-RUZDIDTESA-N
[CAS No.]	1391076-61-1
[MDL No.]	MFCD28502087
[Formula]	C25H25ClN2O4S
[Molecular]	484.99
[Form]	Solid
[Storage]	Store at -20°C

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