TPCA-1 (GW683965) is an IKK-2 inhibitor with an IC50 of 17.9 nM in cell-free tests, which inhibits the NF-κB pathway and is 22 times more selective than for IKK-1. TPCA-1 is also an inhibitor of STAT3 and promotes apoptosis.

 

Brand: BCM

 

Target: IκB/IKK; STAT; Apoptosis

 

Signaling Pathways: NF-κB; JAK/STAT signaling; Stem Cells; Apoptosis

Melting Point: >217°C (dec.)

 

Boiling Point: 442.6±45.0 °C(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

pKa: 13.12±0.50(Predicted)

 

GHS: GHS07

 

Isomeric SMILES: C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F  

 

InChIKey: SAYGKHKXGCPTLX-UHFFFAOYSA-N  

 

InChI: InChI=1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)

 

Attribute
[Chem Name]	2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide
[Synonym]	GW683965; TPCA-1
[CAS No.]	507475-17-4
[MDL No.]	MFCD09037541
[Formula]	C12H10FN3O2S
[Molecular]	279.29
[Form]	White to light brown
[Storage]	Keep in dark place. Sealed in dry, 2-8°C

Goods Tag