S3I-201 (NSC 74859) effectively inhibited the DNA-binding activity of STAT3 with IC50 of 86 μM, while the inhibitory activity of STAT1 and STAT5 was low.

 

Brand: BCM

 

Target: STAT3:86 nM (cell free)

 

Signaling Pathways: Stem Cells; JAK/STAT signaling

 

Melting Point: ＞185°C

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

pKa: 2.98±0.10(Predicted)

 

GHS: GHS07

 

Isomeric SMILES: CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O  

 

InChIKey: HWNUSGNZBAISFM-UHFFFAOYSA-N  

 

InChI: InChI=1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)

 

Attribute
[Chem Name]	2-hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid
[Synonym]	S3I-201; NSC 74859
[CAS No.]	501919-59-1
[MDL No.]	MFCD09907564
[Formula]	C16H15NO7S
[Molecular]	365.36
[Form]	White to beige powder
[Storage]	Inert atmosphere. Store in freezer, under -20°C

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