SH-4-54 is a potent STAT inhibitor with STAT3 and STAT5 KD of 300 nM and 464 nM, respectively.

 

Brand: BCM

 

Target: STAT3:300 nM(Kd), STAT5:464 nM(Kd)

 

Signaling Pathways: Stem Cells; JAK/STAT signaling

 

Boiling Point: 717.2±70.0 °C(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol (warmed with 50ºC water bath). Insoluble in Water.

 

pKa: 4.29±0.10(Predicted)

GHS: GHS07

 

Isomeric SMILES: CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(=O)O)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F  

 

InChIKey: VFPYGNNOSJWBHF-UHFFFAOYSA-N  

 

InChI: InChI=1S/C29H27F5N2O5S/c1-35(42(40,41)28-26(33)24(31)23(30)25(32)27(28)34)16-22(37)36(21-13-11-20(12-14-21)29(38)39)15-17-7-9-19(10-8-17)18-5-3-2-4-6-18/h7-14,18H,2-6,15-16H2,1H3,(H,38,39)

 

Attribute
[Chem Name]	4-[(4-cyclohexylphenyl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]benzoic acid
[Synonym]	SH-4-54
[CAS No.]	1456632-40-8
[MDL No.]	MFCD28143917
[Formula]	C29H27F5N2O5S
[Molecular]	610.59
[Form]	A crystalline solid
[Storage]	Sealed in dry, 2-8°C

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