Trk-in-9 is a potent TRK inhibitor. Trk-IN-9 inhibited the proliferation of Km-12 cell line. Trk-IN-9 induced apoptosis of Km-12 cells in a concentration-dependent manner. Trk-in-9 inhibits phosphorylation of TRK to block the downstream pathway. Trk-IN-9 has the potential to study NTRK-fused cancers.

 

Brand: BCM

 

Target: Trk Receptor

 

InChi Key: RZNISMHVFCHDBI-GOSISDBHSA-N

 

SMILES Code: O=C(N[C@H]1CNCCC1)C2=CC=CC(NC3=NC=C(Cl)C(N(C4=CC=CC(F)=C4)C)=N3)=C2

 

InChi Code: InChI=1S/C23H24ClFN6O/c1-31(19-9-3-6-16(25)12-19)21-20(24)14-27-23(30-21)29-17-7-2-5-15(11-17)22(32)28-18-8-4-10-26-13-18/h2-3,5-7,9,11-12,14,18,26H,4,8,10,13H2,1H3,(H,28,32)(H,27,29,30)/t18-/m1/s1

 

Attribute
[Chem Name]	3-[[5-chloro-4-[(3-fluorophenyl)methylamino]pyrimidin-2-yl]amino]-N-[(3R)-piperidin-3-yl]benzamide
[CAS No.]	2758623-12-8
[Formula]	C23H24ClFN6O
[Molecular]	454.93
[Form]	Powder
[Storage]	Sealed in dry. -20°C
[Synonym]	Trk-IN-9

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