SB-334867 free base is a selective orexin-1 (OX1) receptor antagonist with a pKb of 7.4 for OX2, a 100-fold selectivity for 5-HT2B and 5-HT2C, and pKi values of 5.4 and 5.3, respectively. It reduces ethanol consumption and also inhibits the acquisition of morphine-induced sensitivity to motor activity in the body.

 

Brand: BCM

 

Target: orexin-B:100 nM, orexin-A:10 nM

 

Signaling Pathways: GPCR/G Protein; Neuroscience

 

Boiling Point: 549.5±58.0 °C at 760 mmHg

 

Flashing Point: 286.1±32.3 °C

 

Vapour Pressure: 0.0±1.5 mmHg at 25°C

 

Solubility: Soluble in DMSO; soluble in Ethanol (warmed with 50ºC water bath). Insoluble in Water.

 

pKa: 10.21±0.43(Predicted)

 

GHS: GHS07

Isomeric SMILES: CC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4  

 

InChIKey: AKMNUCBQGHFICM-UHFFFAOYSA-N  

 

InChI: InChI=1S/C17H13N5O2/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14/h2-9H,1H3,(H2,18,21,22,23) 

 

Attribute
[Synonym]	SB-334867; SB334867; SB 334867; SB-334867 free base
[CAS No.]	792173-99-0
[MDL No.]	MFCD06411602
[Formula]	C17H13N5O2
[Molecular]	319.32
[Form]	White to beige powder
[Risk Codes]	H315
[Storage]	Sealed in dry. Room Temperature
[Chem Name]	1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea

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