Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with an EC50 of about 3 nM in Shh-LIGHT2 cells.

 

Brand: BCM

 

Target: Kd: 59 nM (Smo)

 

Solubility: soluble in DMSO (warmed with 50ºC water bath); soluble in Water; soluble in Ethanol (warmed with 50ºC water bath).

 

GHS: GHS07

 

Isomeric SMILES: CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl.Cl  

 

InChIKey: CRWTYWYPPITOOZ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C28H28ClN3OS.ClH/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20;/h2-8,13-17,22-23,30H,9-12,18H2,1H3;1H

 

Attribute
[Chem Name]	3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide;hydrochloride
[Synonym]	SAG hydrochloride; SAG HCl; Smoothened Agonist (SAG) HCl
[CAS No.]	2095432-58-7
[Formula]	C28H29Cl2N3OS
[Molecular]	526.52
[Form]	Powder
[Risk Codes]	H302-H315-H319-H335
[Storage]	Inert atmosphere, 2-8°C

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