A-769662 is A potent, reversible AMPK activator with an EC50 of 0.8 μM in cell-free trials and little effect on GPPase/FBPase activity.

 

Brand: BCM

 

Target: Fatty Acid Synthase; AMPK

 

Signaling Pathways: Chromatin/Epigenetic; Metabolism; PI3K/Akt/mTOR signaling

 

Melting Point: 263 - 266°C

 

Boiling Point: 630.1±55.0 °C(Predicted)

 

Flashing Point: 334.9℃

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

pKa: 4.50±1.00(Predicted)

 

Isomeric SMILES: C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O  

 

InChIKey: CTESJDQKVOEUOY-UHFFFAOYSA-N  

 

InChI: InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25) 

 

Attribute
[Chem Name]	4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile
[Synonym]	A-769662; A 769662;
[CAS No.]	844499-71-4
[MDL No.]	MFCD11977269
[Formula]	C20H12N2O3S
[Molecular]	360.39
[Form]	Beige solid
[Storage]	Keep in dark place. Sealed in dry. Room Temperature

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