TL-895 is an ATP-competitive, and highly selective irreversible inhibitor of Bruton’s Tyrosine Kinase(BTK). TL-895 showed good potency with an IC50 of 1.5 nM and a Ki of 11.9 nM.

 

Brand: BCM

 

Target: BTK

 

Signaling Pathways: Angiogenesis; Tyrosine Kinase/Adaptors

 

Boiling Point: 685.0±55.0 °C(Predicted)

 

pKa: 5.29±0.10(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: C=CC(=O)N1CCC(CC1)(CNC2=NC=NC(=C2C3=CC=C(C=C3)OC4=CC=CC=C4)N)F  

 

InChIKey: OXOXFDSEGFLWLU-UHFFFAOYSA-N  

 

InChI: InChI=1S/C25H26FN5O2/c1-2-21(32)31-14-12-25(26,13-15-31)16-28-24-22(23(27)29-17-30-24)18-8-10-20(11-9-18)33-19-6-4-3-5-7-19/h2-11,17H,1,12-16H2,(H3,27,28,29,30) 

 

Attribute
[Chem Name]	1-[4-[[[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino]methyl]-4-fluoropiperidin-1-yl]prop-2-en-1-one
[Synonym]	M7583; M-7583; M7583; TL-895; TL895
[CAS No.]	1415823-49-2
[MDL No.]	MFCD34567755
[Formula]	C25H26FN5O2
[Molecular]	447.5
[Form]	Solid Powder
[Storage]	Powder: -20°C for 3 years. In solvent: -80°C for 2 years

Goods Tag