MAZ51 is a selective inhibitor of vascular endothelial growth factor receptor (VEGFR)-3 (Flt-4) tyrosine kinase. MAZ51 induces cell rounder and G2/M cell cycle arrest in glioma cells through Akt/GSK3β phosphorylation and RhoA activation. MAZ51 can inhibit the proliferation and induce apoptosis of a variety of non-VEGFR-3 expressing tumor cells.

 

Brand: BCM

 

Target: VEGFR; Apoptosis

 

Signaling Pathways: Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CN(C)C1=CC=C(C2=CC=CC=C21)C=C3C4=CC=CC=C4NC3=O  

 

InChIKey: VFCXONOPGCDDBQ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C21H18N2O/c1-23(2)20-12-11-14(15-7-3-4-9-17(15)20)13-18-16-8-5-6-10-19(16)22-21(18)24/h3-13H,1-2H3,(H,22,24)

 

Attribute
[Chem Name]	3-[[4-(dimethylamino)naphthalen-1-yl]methylidene]-1H-indol-2-one
[Synonym]	MAZ51; MAZ 51; MAZ-51
[CAS No.]	163655-37-6
[MDL No.]	MFCD04036983
[Formula]	C21H18N2O
[Molecular]	314.38
[Form]	Orange solid
[Storage]	Keep in dark place. Sealed in dry, 2-8°C

Goods Tag