Tacrolimus (FK506) is a 23-element macrolide that produces a new complex by binding to the immunosuppressant protein FKBP12 (FK506 binding protein), thereby reducing peptidyl prolyl isomerase activity in T cells. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus can induce autophagy of vascular endothelial cells.

 

Brand: BCM

 

Target: Phosphatase; Others; Antibacterial; Antibiotic; mTOR; Autophagy

 

Signaling Pathways: Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling

 

Melting Point: 113-115°C

 

Boiling Point: 871.7±75.0 °C(Predicted)

 

Flashing Point: 2℃

 

pKa: 9.97±0.70(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

GHS: GHS06, GHS08

 

Isomeric SMILES: C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC  

 

InChIKey: QJJXYPPXXYFBGM-LFZNUXCKSA-N  

 

InChI: InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1 

 

Attribute
[Chem Name]	(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
[Synonym]	Tacrolimus; FK506; FR900506; Fujimycin
[CAS No.]	104987-11-3
[EINECS]	1308068-626-2
[MDL No.]	MFCD00869853
[Formula]	C44H69NO12
[Molecular]	804.02
[Form]	White solid
[Storage]	Sealed in dry,Store in freezer, under -20°C

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