MRT67307 (IKKε/TBK1 Inhibitor II) inhibited IKKϵ/TBK1. IC50 of MRT67307 was 160 and 19 nM, respectively, in vitro ATP (final concentration 0.1mM) experiment. However, it had no inhibitory effect on IKα and IKβ when concentration was 10 μM. MRT67307 is also an inhibitor of ULK1 and ULK2 with IC50 of 45 and 38 nM, respectively. MRT67307 blocks autophagy in cells.

 

Brand: BCM

 

Target: TBK1:190 nM, IKKϵ:160 nM

 

pKa: 15.94±0.20(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: C1CC(C1)C(=O)NCCCNC2=NC(=NC=C2C3CC3)NC4=CC=CC(=C4)CN5CCOCC5  

 

InChIKey: UKBGBACORPRCGG-UHFFFAOYSA-N  

 

InChI: InChI=1S/C26H36N6O2/c33-25(21-5-2-6-21)28-11-3-10-27-24-23(20-8-9-20)17-29-26(31-24)30-22-7-1-4-19(16-22)18-32-12-14-34-15-13-32/h1,4,7,16-17,20-21H,2-3,5-6,8-15,18H2,(H,28,33)(H2,27,29,30,31)

 

Attribute
[Chem Name]	N-[3-[[5-cyclopropyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
[Synonym]	MRT67307; IKKε/TBK1 Inhibitor II; MRT67307 HCl
[CAS No.]	1190378-57-4
[MDL No.]	MFCD19443643
[Formula]	C26H36N6O2
[Molecular]	464.60
[Form]	White to light brown powder
[Storage]	Keep in dark place. Sealed in dry, 2-8°C

Goods Tag