QNZ (EVP4593) effectively inhibits NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM, respectively, in Jurkat T cells.

 

Brand: BCM

 

Target: TNF; NF-κB

 

Signaling Pathways: Apoptosis; NF-κB

 

Melting Point: 169-175°C

 

Solubility: Soluble in DMSO (warmed with 50ºC water bath). Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07, GHS09

 

Isomeric SMILES: C1=CC=C(C=C1)OC2=CC=C(C=C2)CCNC3=NC=NC4=C3C=C(C=C4)N  

 

InChIKey: IBAKVEUZKHOWNG-UHFFFAOYSA-N  

 

InChI: InChI=1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)

 

Attribute
[Chem Name]	4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine
[Synonym]	QNZ; EVP4593
[CAS No.]	545380-34-5
[MDL No.]	MFCD06411436
[Formula]	C22H20N4O
[Molecular]	356.42
[Form]	White to beige powder
[Storage]	Keep in dark place. Inert atmosphere, 2-8°C

Goods Tag