Iwr-1-endo (Endo-IWR-1, IWR-1), a Wnt pathway inhibitor with an IC50 of 180 nM in Wnt3a-expressing L-cells, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing the Axin skeleton destruction complex.

 

Brand: BCM

 

Target: Wnt:0.2 nM(EC50)

 

Signaling Pathways: Cytoskeletal Signaling; Stem Cells

 

Specific Rotation: -3.0～+3.0°(20℃/D)(c=0.1,CH3CN)

 

Boiling Point: 643.9±55.0 °C(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C1[C@@H]2C=C[C@H]1[C@@H]3[C@H]2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6  

 

InChIKey: ZGSXEXBYLJIOGF-ALFLXDJESA-N  

 

InChI: InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,20-21H,13H2,(H,27,29)/t16-,17+,20-,21+

 

Attribute
[Chem Name]	4-[(1S,2R,6S,7R)-3,5-dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]-N-quinolin-8-ylbenzamide
[Synonym]	IWR-1-endo; endo-IWR 1; IWR-1
[CAS No.]	1127442-82-3
[MDL No.]	MFCD18086875
[Formula]	C25H19N3O3
[Molecular]	409.44
[Form]	White to beige liquid
[Storage]	Sealed in dry, 2-8°C

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