Pulrodemstat (CC-90011) besylate (LSD1-in-7 benzenesulfonate) is a potent oral active lysine specific demethylase-1 (LSD1) inhibitor. And has been found to be effective in a variety of tumor treatments.

 

Brand: BCM

 

Target: Histone Demethylase

 

Signaling Pathways: Chromatin/Epigenetic

 

In Vivo: LSD1-IN-7 in combination with other LSD1 inhibitor can be treatment of cancer in a mammal, including breast cancer, lung cancer, prostate cancer, glioblastoma, or leukemia.

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CN1C(=O)C(=C(N=C1N2CCC(CC2)N)C3=CC(=C(C=C3)C#N)F)C4=CC(=C(C=C4)OC)F.C1=CC=C(C=C1)S(=O)(=O)O  

 

InChIKey: AWZCBGWZNHQCIZ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C24H23F2N5O2.C6H6O3S/c1-30-23(32)21(14-5-6-20(33-2)19(26)11-14)22(15-3-4-16(13-27)18(25)12-15)29-24(30)31-9-7-17(28)8-10-31;7-10(8,9)6-4-2-1-3-5-6/h3-6,11-12,17H,7-10,28H2,1-2H3;1-5H,(H,7,8,9) 

 

Attribute
[Chem Name]	4-[2-(4-aminopiperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxopyrimidin-4-yl]-2-fluorobenzonitrile;benzenesulfonic acid
[Synonym]	Pulrodemstat (CC-90011) besylate; CC-90011; LSD1-IN-7 benzenesulfonate
[CAS No.]	2097523-60-7
[MDL No.]	MFCD32644589
[Formula]	C30H29F2N5O5S
[Molecular]	609.65
[Form]	Solid powder
[Storage]	Inert atmosphere, 2-8°C

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