AG-270 is a potent, non-competitive methionine adenosyltransferase 2A (MAT2A) inhibitor that reduces intracellular SAM levels and MTAP-NULL-selective anti-proliferative activity.

 

Brand: BCM

 

Target: Others; Methionine Adenosyltransferase (MAT)

 

Signaling Pathways: Chromatin/Epigenetic; Others

 

In Vitro: AG-270 exhibits an IC50 of 20 nM in HCT116 MTAP-null cell SAM at 72 h[1].AG-270 demonstrates potent reduction in levels of intracellular SAM, as well as MTAP-null–selective antiproliferative activity in the HCT116 MTAP isogenic cell model in vitro

 

Boiling Point: 709.3±70.0 °C(Predicted)

 

pKa: 7.30±0.10(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol. 

 

GHS: GHS05, GHS07

 

Isomeric SMILES: COC1=CC=C(C=C1)C2=C(N=C3C(=C(NN3C2=O)C4=CC=CC=C4)C5=CCCCC5)NC6=CC=CC=N6  

 

InChIKey: LSOYYWKBUKXUHQ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C30H27N5O2/c1-37-23-17-15-21(16-18-23)26-28(32-24-14-8-9-19-31-24)33-29-25(20-10-4-2-5-11-20)27(34-35(29)30(26)36)22-12-6-3-7-13-22/h3,6-10,12-19,34H,2,4-5,11H2,1H3,(H,31,32)

 

Attribute
[Chem Name]	3-(cyclohexen-1-yl)-6-(4-methoxyphenyl)-2-phenyl-5-(pyridin-2-ylamino)-1H-pyrazolo[1,5-a]pyrimidin-7-one
[Synonym]	AG-270
[CAS No.]	2201056-66-6
[MDL No.]	MFCD34368529
[Formula]	C30H27N5O2
[Molecular]	489.57
[Form]	Solid powder
[Storage]	Keep in dark place. Sealed in dry, 2-8°C

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