Rhein (Monorhein, NSC 38629, Rheinic), a component of Rhubarb, is isolated from Rheum coreanum Nakai fresh rhizomes and has anti-inflammatory and antitumor activities. Rhein is an inhibitor of FTO (mRNA N6-methyladenine demethylase) and also inhibits AlkB repair enzymes.

 

Brand: BCM

 

Target: Reactive Oxygen Species; Antibacterial; Autophagy

 

Signaling Pathways: Autophagy; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB

 

Melting Point: ≥300 °C (lit.)

 

Boiling Point: 346.72°C (rough estimate)

 

pKa: 3.17±0.20(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Stability: Hygroscopic

 

GHS: GHS07

 

Isomeric SMILES: C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)C(=O)O  

 

InChIKey: FCDLCPWAQCPTKC-UHFFFAOYSA-N  

 

InChI: InChI=1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)

 

Attribute
[Chem Name]	4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid
[Synonym]	Rheic Acid; Rhein; Monorhein; NSC 38629
[CAS No.]	478-43-3
[EINECS]	207-521-4
[MDL No.]	MFCD00009618
[Formula]	C15H8O6
[Molecular]	284.22
[Form]	Yellow to Dark Orange Solid Powder
[Storage]	Inert atmosphere. Room Temperature

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