FB23-2 is a potent and selective inhibitor of FTO, which can bind directly to FTO and selectively inhibit the activity of N6-methyladenosine (m6A) demethylase of FTO with an IC50 value of 2.6 μM.

 

Brand: BCM

 

Target: FTO:2.6 μM (IC50)

 

Signaling Pathways: Apoptosis; Others

 

λmax: 216 nm

 

In Vitro: FB23-2 directly binds to FTO and selectively inhibits FTO’s m6A demethylase activity. Mimicking FTO depletion, FB23-2 dramatically suppresses proliferation and promotes the differentiation/apoptosis of human acute myeloid leukemia (AML) cell line cells and primary blast AML cells in vitro.

 

pKa: 8.72±0.40(Predicted)

 

Solubility: Insoluble in DMSO; insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CC1=C(C(=NO1)C)C2=CC(=C(C(=C2)Cl)NC3=CC=CC=C3C(=O)NO)Cl  

 

InChIKey: ILHNIWOZZKIBNW-UHFFFAOYSA-N  

 

InChI: InChI=1S/C18H15Cl2N3O3/c1-9-16(10(2)26-23-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(24)22-25/h3-8,21,25H,1-2H3,(H,22,24)

 

Attribute
[Chem Name]	2-[2,6-dichloro-4-(3,5-dimethyl-1,2-oxazol-4-yl)anilino]-N-hydroxybenzamide
[Synonym]	FB23-2; FTO Demethylase inhibitor FB23-2
[CAS No.]	2243736-45-8
[MDL No.]	MFCD32174281
[Formula]	C18H15Cl2N3O3
[Molecular]	392.24
[Form]	White to light yellow solid powder
[Storage]	Protect from light. Inert atmosphere, 2-8°C

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