GW806742X is an effective inhibitor of MLKL (Mixed Lineage Kinase domain-like protein) and binds to the MLKL pseudokinase Domain with Kd of 9.3 μM. GW806742X delays MLKL membrane translocation and inhibits necrotic apoptosis.

 

Brand: BCM

 

Target: MLK; VEGFR

 

Signaling Pathways: Angiogenesis; MAPK; Tyrosine Kinase/Adaptors

 

pKa: 10.09±0.60(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: CN(C1=CC=C(C=C1)NC(=O)NC2=CC=C(C=C2)OC(F)(F)F)C3=NC(=NC=C3)NC4=CC(=CC=C4)S(=O)(=O)N  

 

InChIKey: SNRUTMWCDZHKKM-UHFFFAOYSA-N  

 

InChI: InChI=1S/C25H22F3N7O4S/c1-35(22-13-14-30-23(34-22)31-18-3-2-4-21(15-18)40(29,37)38)19-9-5-16(6-10-19)32-24(36)33-17-7-11-20(12-8-17)39-25(26,27)28/h2-15H,1H3,(H2,29,37,38)(H,30,31,34)(H2,32,33,36)

 

Attribute
[Chem Name]	1-[4-[methyl-[2-(3-sulfamoylanilino)pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethoxy)phenyl]urea
[Synonym]	GW806742X
[CAS No.]	579515-63-2
[Formula]	C25H22F3N7O4S
[Molecular]	573.55
[Form]	Solid powder
[Storage]	Keep in dark place. Inert atmosphere. Room temperature
[MDL No.]	MFCD29036385

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