INF39 is a non-toxic, irreversible inhibitor of NLRP3, blocking NLRP3 activation through direct and irreversible interaction with NLRP3 and partial inhibition of LPS-driven pro-inflammatory gene expression.

 

Brand: BCM

 

Target: NOD; NOD-like Receptor (NLR)

 

Signaling Pathways: Immunology/Inflammation; NF-κB

 

In Vitro: INF39 possibly reacts with Cys-SH residues in the active site of cysteine protease caspase-1 but does not directly inhibit caspase-1 activity. INF39 (10 μM) can markedly inhibit ATP- and nigericin-induced IL-1β release. In the macrophages, INF39 suppresses caspase-1 activation and pyroptosis. INF39 can also block the NF-κB pathway. INF39 can reduce the steady-state (or basal) BRET signal of NLRP3, and not affect the viability of cells. INF39 cannot affect the initial conformational changes suffered by NLRP3 upon sensing the decrease of intracellular K+, but it affects the second step of NLRP3 conformational change. INF39 reaches the intestinal epithelium without undergoing chemical modifications. It is likely to act locally at the mucosal epithelial level after absorption into epithelial cells.

 

Boiling Point: 309.3±30.0 °C at 760 mmHg

 

Flashing Point: 149.6±20.0 °C

 

Vapour Pressure: 0.0±0.7 mmHg at 25°C

 

Solubility: Soluble in DMSO.

 

GHS: GHS07

 

Isomeric SMILES: CCOC(=O)C(=C)CC1=CC=CC=C1Cl  

 

InChIKey: VTAOWWAFBSFWSG-UHFFFAOYSA-N  

 

InChI: InChI=1S/C12H13ClO2/c1-3-15-12(14)9(2)8-10-6-4-5-7-11(10)13/h4-7H,2-3,8H2,1H3

 

Attribute
[Chem Name]	ethyl 2-[(2-chlorophenyl)methyl]prop-2-enoate
[Synonym]	INF39; INF-39
[CAS No.]	866028-26-4
[MDL No.]	MFCD27930542
[Formula]	C12H13ClO2
[Molecular]	224.68
[Form]	Colorless to light brown oil
[Storage]	Sealed in dry。 Store in freezer, under -20°C

Goods Tag