SKI II (SPHK-I2) is a highly selective, non-ATP-competitive inhibitor of sphingosine kinase (SphK) with an IC50 of 0.5 μM and no inhibitory effect on other kinases, including PI3K, PKCα, and ERK2.

 

Brand: BCM

 

Target: Wnt/beta-catenin; Apoptosis; S1P Receptor

 

Signaling Pathways: Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Stem Cells

 

Boiling Point: 507.1±60.0 °C at 760 mmHg

 

Flashing Point: 260.5±32.9 °C

 

Vapour Pressure: 0.0±1.4 mmHg at 25°C

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl  

 

InChIKey: ZFGXZJKLOFCECI-UHFFFAOYSA-N  

 

InChI: InChI=1S/C15H11ClN2OS/c16-11-3-1-10(2-4-11)14-9-20-15(18-14)17-12-5-7-13(19)8-6-12/h1-9,19H,(H,17,18)

 

Attribute
[Chem Name]	4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol
[Synonym]	SKI II; SphK-I2
[CAS No.]	312636-16-1
[MDL No.]	MFCD00733553
[Formula]	C15H11ClN2OS
[Molecular]	302.78
[Form]	Off-white solid powder
[Storage]	Sealed in dry, 2-8°C

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