H89 2HCl is a potent PKA inhibitor with a Ki of 48 nM in cell-free tests and is 10 times more selective on PKA than on PKG and 500 times more selective on PKC, MLCK, calmodulin kinase II and casein kinase I/II. H 89 2HCl can induce autophagy.

 

Brand: BCM

 

Target: S6 Kinase; PKA; Autophagy

 

Signaling Pathways: Autophagy; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors

 

Melting Point: 195-200ºC

 

Solubility: Soluble in DMSO; soluble in Water. Insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNC/C=C/C3=CC=C(C=C3)Br.Cl.Cl  

 

InChIKey: GELOGQJVGPIKAM-WTVBWJGASA-N  

 

InChI: InChI=1S/C20H20BrN3O2S.2ClH/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;/h1-10,12,15,22,24H,11,13-14H2;2*1H/b3-2+;;

 

Attribute
[Chem Name]	N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide;dihydrochloride
[Synonym]	H 89 2HCl; H-89 HCL; H-89 dihydrochloride hydrate
[CAS No.]	130964-39-5
[MDL No.]	MFCD00214120
[Formula]	C20H20BrN3O2S.2ClH.H2O
[Molecular]	537.304
[Form]	Off-white powder
[Storage]	Keep in dark place. Inert atmosphere. Room temperature

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