GNE-9815 is a highly selective panRAF inhibitor with good oral bioavailability. The Ki values of GNE-9815 for c-Raf and b-Raf are 0.062 and 0.19 nM, respectively.

 

Brand: BCM

 

Target: Raf

 

Signaling Pathways: MAPK

 

pKa: 11.77±0.70(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC1=CC(=C(C=C1C2=CN=C3C(=C2)C=NN(C3=O)C)NC(=O)C4=CC(=CC=C4)C(C)(C)C#N)F  

 

InChIKey: SXCTZLXYGLXXRY-UHFFFAOYSA-N  

 

InChI: InChI=1S/C26H22FN5O2/c1-15-8-21(27)22(31-24(33)16-6-5-7-19(10-16)26(2,3)14-28)11-20(15)17-9-18-13-30-32(4)25(34)23(18)29-12-17/h5-13H,1-4H3,(H,31,33) 

 

Attribute
[Chem Name]	3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxopyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide
[Synonym]	GNE-9815
[CAS No.]	2729996-45-4
[Formula]	C26H22FN5O2
[Molecular]	455.49
[Form]	Solid powder
[Storage]	Stored at -20°C

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