Vemurafenib (PLX4032, RG7204, RO5185426) is a novel and potent B-RafV600E inhibitor with an IC50 of 31 nM. The selectivity of Vemurafenib to B-RafV600E is 10 times higher than that of wild type B-Raf, and in cell experiments, the selectivity can be more than 100 times higher. Vemurafenib (PLX4032, RG7204) can induce autophagy.

 

Brand: BCM

 

Target: Autophagy; ACK; MAPK; Raf; Src

 

Signaling Pathways: Angiogenesis; Autophagy; MAPK; Tyrosine Kinase/Adaptors

 

pKa: 6.26±0.10(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS09

 

Isomeric SMILES: CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F  

 

InChIKey: GPXBXXGIAQBQNI-UHFFFAOYSA-N  

 

InChI: InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)

 

Attribute
[Chem Name]	N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide
[Synonym]	PLX4032; PLX-4032; Vemurafenib; RG7204; RO5185426
[CAS No.]	918504-65-1
[MDL No.]	MFCD18074504
[Formula]	C23H18ClF2N3O3S
[Molecular]	489.92
[Form]	White to off-white powder
[Storage]	Sealed in dry, 2-8°C

Goods Tag