LY03009120 (DP-4978) is A potent pan-RAF inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-Raf, B-Raf, and C-Raf in A375 cells, respectively. LY03009120 can induce autophagy. Phase 1.

 

Brand: BCM

 

Target: Raf; Autophagy

 

Signaling Pathways: Autophagy; MAPK

 

In Vitro: LY3009120 inhibits the cell growth of A375 and HCT116 cells with the IC50 of 9.2 and 220 μM, respectively. LY3009120 inhibits the tyrosine kinase KDR with the IC50 of 3.9 μM.

 

pKa: 13.52±0.70(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CC1=CC(=C(C=C1C2=C(N=C3C(=C2)C=NC(=N3)NC)C)NC(=O)NCCC(C)(C)C)F  

 

InChIKey: HHCBMISMPSAZBF-UHFFFAOYSA-N  

 

InChI: InChI=1S/C23H29FN6O/c1-13-9-18(24)19(29-22(31)26-8-7-23(3,4)5)11-16(13)17-10-15-12-27-21(25-6)30-20(15)28-14(17)2/h9-12H,7-8H2,1-6H3,(H2,26,29,31)(H,25,27,28,30)

 

Attribute
[Chem Name]	1-(3,3-dimethylbutyl)-3-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]urea
[Synonym]	LY03009120; DP-4978
[CAS No.]	1454682-72-4
[MDL No.]	MFCD28411374
[Formula]	C23H29FN6O
[Molecular]	424.51
[Form]	Solid powder
[Storage]	Keep in dark place. Sealed in dry. Store in freezer, under -20°C

Goods Tag