A-83-01 is A potent inhibitor of TGF-β type I receptor (ALK5-TD) with an IC50 value of 12 nM. A-83-01 also inhibits transcription induced by activin/nodal type I receptor (ALK4-TD) and nodal type I receptor (ALK7-TD), with corresponding IC50 values of 45 nM and 7.5 nM, respectively.

 

Brand: BCM

 

Target: ALK; TGF-beta/Smad

 

Signaling Pathways: Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors

 

Boiling Point: 590ºC at 760 mmHg

 

Flashing Point: 310.6ºC

 

Melting Point: 111℃

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CC1=NC(=CC=C1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5  

 

InChIKey: HIJMSZGHKQPPJS-UHFFFAOYSA-N  

 

InChI: InChI=1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31)

 

Attribute
[Chem Name]	3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide
[Synonym]	A-83-01
[CAS No.]	909910-43-6
[MDL No.]	MFCD08705403
[Formula]	C25H19N5S
[Molecular]	421.52
[Form]	White to beige powder
[Storage]	Sealed in dry. Store in freezer, under -20°C

Goods Tag